Phenotypic Switching in Cryptococcus neoformans Results in Changes in Cellular Morphology and Glucuronoxylomannan Structure
نویسندگان
چکیده
منابع مشابه
Cryptococcus neoformans of unusual morphology.
A case of primary cryptococcosis of the lungs was caused by an isolate of Cryptococcus neoformans that assumes a giant form in tissue but which has a normal appearance on artificial culture. Electron microscopy revealed gross enlargement of the capsule and plasma membranes in the tissue form.
متن کاملPhenotypic switching of Cryptococcus neoformans occurs in vivo and influences the outcome of infection.
Phenotypic switching has been linked to the virulence of many pathogens, including fungi. However, it has not been conclusively shown to occur in vivo or to influence the outcome of infection. Cryptococcus neoformans undergoes phenotypic switching in vitro to colony types that differ in their virulence in mice. In this study, we asked whether C. neoformans undergoes phenotypic switching in vivo...
متن کاملIt infects me, it infects me not: phenotypic switching in the fungal pathogen Cryptococcus neoformans.
Phenotypic switching has been observed in both prokaryotes and eukaryotes and involves stochastic switching between two or more alternative and heritable phenotypes, usually distinguished by surface antigenicity. This strategy, generally adopted by pathogens to escape recognition by the immune system and to adapt to a hostile host environment, results from spontaneous alterations in gene expres...
متن کاملDETECTION OF CRYPTOCOCCUS NEOFORMANS BY SEMINESTED PCR IN CEREBROSPINAL FLUID
ABSTRACT Life-threatening infections caused by the encapsulated fungal pathogen Cryptococcus neoformans have been increasing steadily over the past 10 years. Cryptococcus neoformans is recognized as the most frequent fungal infection of the central nervous system (CNS) in immunocompetent as well as immunocompromised patients. We report the development of a semi-nested- PCR-based assay for the ...
متن کاملCryptococcus neoformans variants generated by phenotypic switching differ in virulence through effects on macrophage activation.
Macrophages have a central role in the pathogenesis of cryptococcosis since they are an important line of defense, serve as a site for fungal replication, and also can contribute to tissue damage. The objective of this study was to investigate the interaction of macrophages with cells from smooth-colony variants (SM) and mucoid-colony variants (MC) arising from phenotypic switching of Cryptococ...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1999
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.67.11.6076-6083.1999